Lisa was asked to host the 3rd Annual 2000 MOBO Awards Show in the United Kingdom. Accepting the offer made Lisa the first African American Woman to host the MOBO Awards. Bill Bellamy was the first African American Male to host the show, Melanie B. (Spice Girls) was the first African European Woman, and then Lisa, co-hosting with DJ Trevor Nelson. She used her platform not only bring up taboo topics every chance she had (like the bad chemicals we feed our chickens, how bad the water is verses the water in Honduras), but wear 6 different outfits made by her Uncle, Kyle Young, wearing 5 different wigs, different shoes, thanking LA Reid for bailing her out of jail while presenting him an award, and do another performance outside of TLC with Donell Jones for their song "U Know What's Up (Remix)" such ended up being her last performance outside the group. Also, the last TV show she hosted/co-hosted.